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KMID : 1007520140230010293
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Food Science and Biotechnology
2014 Volume.23 No. 1 p.293 ~ p.297
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Extracts of the Seaweed Sargassum macrocarpum Inhibit the CpGInduced Inflammatory Response by Attenuating the NF-κB Pathway
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Zahid Manzoor
Vivek Bhakta Mathema
Chae Doo-Byeong
Yoo Eun-Sook
Kang Hee-Kyoung
Hyun Jin-Won
Lee Nam-Ho
Ko Mi-Hee
Koh Young-Sang
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Abstract
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The anti-inflammatory effects of extracts of the seaweed Sargassum macrocarpum (SME) in bone marrow-derived macrophages (BMDMs) and dendritic cells (BMDCs) were investigated. Primary BMDMs and BMDCs were used for cytokine production and western blot analysis. SME (0?50 μg/mL) pre-treatment resulted in a strong inhibitory effect against interleukin (IL)-12 p40, IL-6, and tumor necrosis factor (TNF)-α production in CpG-stimulated BMDMs and BMDCs. SME pre-treatment caused a strong inhibitory effect against NF-κB activation, as evaluated using degradation of IκBα and the NF-κB reporter gene assay. SME has significant anti-inflammatory properties and warrants further study regarding potential use as a medicinal food.
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KEYWORD
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Sargassum macrocarpum, interleukin, nuclear factor kappa-light-chain-enhancer of activated B cells, pro-inflammatory cytokine
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